Buccal vs sublingual reddit. Table 1 shows examples of the sublingual and buccal formulations that are approved or in clinical trials. Nov 5, 2019 · Sublingual and Buccal Formulations Approved and in Clinical Trials. Any thoughts if one should keep mewing when having tablet there or better to rest the tongue down until its dissolved? I switched to buccal (in the cheek) or sublabial (under the lip). One example of a buccal medication is cold sore medication acyclovir (Sitavig). Opinions seem to be divided on taking Progynova sublingually Br Med Bull. . The reason I use buccal, is because I couldn't help but swallow some either with sublingual. I insufflate exclusively now for months, and if I forget one of my twice daily-doses, I feel WD within hours. Sublingual medications do have limitations, but it is possible to make improvements. Cannabis tinctures can also be absorbed orally by swallowing the tincture or mixing it into food or a drink. Once it is in your blood stream it doesn't matter, so it comes down to personal preference. 9 Higher plasma concentrations of E2 are achieved than Sublingual: 8-18 hours Transdermal (gel): 37 hours And various shots can have half lives measuring several days. but before this moment comes half of it has already being absorbed by your tounge your esophagus etcetera. If I take the same amount and rub it in under my tongue, would that have the same effect? Or would I need to leave it under my tongue and let the saliva do its job? The bioavailability of sublingual ketamine is 24-30%, and 45-50% for intranasal. There is no good literature about how different dosage regimes affect outcomes, only anecdotes, and plenty to support almost all options. I get some medicine that's sublingual tablets, as in it is placed under the tongue. Bypassing liver first pass metabolism may increase the bioavailability dramatically. In the future, they may improve the formulations of sublingual and buccal medications. Posted by u/just1nfraz13r - 2 votes and 9 comments Posted by u/[Deleted Account] - 3 votes and 1 comment I'm switching from oral to either buccal or sublingual for my E. My anecdotal experience does not contradict that hypothesis: I am on as low of a dose as I can be and still be free of cravings. Sticking it between my lower lip and gums. gov/14628189 When I take it orally, I can def FEEL a big decrease in focus and willingness to sit down around the T+3hr mark. So oral stays in your body slightly longer it seems, but sublingual absorbs into your blood stream more rapidly and results in significantly higher levels. so even by supposing that there is some Is there any difference in the absorption rate/efficiency of sublingual vs. Archived post. The sublingual route may also be used for vaccines against various infectious diseases. In terms of damage, I’d guess it's similar, just targeting a different part. Did I just waste a… We would like to show you a description here but the site won’t allow us. Unfortunately I've not noticed any difference between the two. Depends what your docs goals for you are and your goals, either way might be better for your goals- but how can u decide being brand new. Then it enters the bloodstream. I don’t have any info on the bioavailability of oral vs sublingual and I also dk if there’s any short or long term issues associated with sublingual. When experimenting with my dosage to dial it in, I've found about a 2:1 ratio with sublingual/buccal vs. Those approved for clinical use have varied indications that also I believe so - there are plenty of buccal Vs sublingual posts on Reddit, but for me debating the minutae of percentage absorption rates was secondary to actually absorbing it instead of swallowing it in gulps of saliva! That's why I switched to gels btw but the ease of popjng a pill up my lip is tempting me haha I take mine buccally sometimes (basically 50/50 whether I do sublingual or buccal, mostly just how I feel at the moment. lsd has such a ridiculous ability to pass through skin that even letting it sit on your palm is enough to get you high. , 2013), the sublingual and buccal routes can be inconvenient for patients as it can involve some technical procedures to maintain the drug in the sublingual or buccal area for absorption without swallowing the drug. I had issues with having them migrating, not to mention I could neither speak, drink or eat. Switching to sublingual or buccal isn't likely going to change your results hugely unless you have a terrible liver mutation. Since I'm approximately 11 weeks and some days, I was wondering which route would be better to take for Misoprostol. I prefer buccal to sublingual by a mile and I am wondering why almost everybody is taking their nootropics sublingual when oral isn't as effective. I was wondering if either is better than the other, and also what are the best… We would like to show you a description here but the site won’t allow us. I believe the actually increased bioavailability of sublingual selegiline originated with zydis selegiline which was a special formulation, I'm not sure what the bioavailability is for normal selegiline taken sublingual. It is also in line with a proposed model in which drug rapidly partitions into the mucosal membranes, where it is stored for Oct 18, 2004 · Buccal or sublingual misoprostol for cervical ripening and induction of labour Not enough evidence to say if misoprostol administered under the tongue or in the cheek is safe for induction of labour. I've been taking orally as prescribed for close to 6 years and my levels have always been fine. I was wondering, is there much difference as far as sublingual vs buccal goes for taking E? What I mean is, how does one vs the other work as far as entering the blood stream and impacting E levels? Buccal seems so so so much more convenient, you can talk, drink, swallow etc and not worry where as sublingual doesn't allow anything whatsoever. Place the yellow side of the film against the inside of your cheek. A number of sublingual and buccal formulations are on the market with more in clinical development. sublingual absorption is better, you need to be comparing apples to apples. I'd love to see the lab posted levels for sure, because there are some limited ones about this novel "buccal" buprenorphine that basically has super low mcg dosing (up to 900) but I'm not certain the absorbtion difference vs sublingual I just imagined it was okay since they mentioned it on the little pamphlet in the box (both under the tongue I find once my nose shuts er down for the night, my next 2 doses before calling it a night are sublingual, . To determine whether buccal vs. Sublingual vs Buccal Sublingual seems to be the gold standard for taking oral estradiol, but I struggle to not swallow saliva the pill has dissolved into. I find it takes an hour or two to dissolve fully, and I have no trouble talking or drinking while it dissolves so it’s no inconvenience. Going to try buccal (between cheeks and gums) next. sublingually. Estradiol pills: Swallowing vs sublingual The instructions just say "by mouth" and I can't seem to find any information about this. Just learned the term "buccal" this morning which means dissolving meds inside cheek. A subreddit for questions about transfeminine hormone therapy, also known as male-to-female hormone… I found this paper which did a study taking Estradiol buccal: “Pharmacokinetics of estradiol, progesterone, testosterone and dehydroepiandrosterone after transbuccal administration to postmenopausal women” B. I never swallow any of it before it's all dissolved. I started HRT just over two months ago and my doctor hadn't heard of the benefits of buccal/sublingual as compared to swallowing so I spent two months swallowing before having my levels tested just to start things off the way she's accustomed to. Comparing buccal Bunavail to sublingual bupe/naloxone tablets is comparing apples to oranges b/c the former formulation has higher BA regardless of the ROA. buccal? I'm using Ultrakkana UC extract and have been rubbing a pinch into my gums. People say… main difference is that sublingual/buccal offer more E2 (estradiol), but it also raises your E2 levels dramatically in more of a spike that peaks at 1-2hrs, and falls off 3-4 hours. GameStop Moderna Pfizer Johnson & Johnson AstraZeneca Walgreens Best Buy Novavax SpaceX Tesla. 15. If you have a medical condition, believe you have a medical condition, or are concerned about something your body is doing then seek in-person care from a licensed physician. Use your tongue to wet the inside of your cheek or rinse your mouth with water before placing the film in your mouth. Most people I've seen have been doing it sublingually, but is it possible that I have a different type that I'm supposed to just swallow or something? Lol, I think the downvotes are due to the fact that sublingually is NOT the only "correct" way to take your Suboxone, it literally says in the medication guide in each box that it can be taken sublingual or buccal. Would holding it in the cheek absorb it through the bloodstream just like under the tongue? Sublingual/buccal intake does cause a large spike in blood estradiol levels, which is correct but the absolute increase in clotting risk from this is minimal (the danger is consistently and massively elevated levels), and can be further mitigated by just splitting your dose up. Buccal (top or lower, although I prefer top) could take up to 40 mins, which I used mostly and was giving great results. The effects of the drug are felt very fast and seem to have drastically more intense effects vs straight sublingual or oral administration so if you do try this start at 1/3rd or less of what you normally would ingest to start. Then I learned of buccal absorption from a post menopausal HRT group. ncbi. Is there a difference? The dr prescribed me to take subs in the cheek, I took it under the tongue without reading the package. With sublingual, the comedown feels more gradual. I've changed up the administration of my subs from sublingual to buccal after seeing a few posts about how it's better absorbed buccally. I split my I switched from sublingual administration to transbuccal administration because I fail at sublingual, and saw an increase of E2 levels. nlm. So I’ve been on and off subs for quite a few years now but I’ve always taken them under my tongue. It’s similarly effective because both areas have plenty of blood vessels and permeable membranes. You may find that buccal takes longer/is more difficult to dissolve though, as it should be exposed to less saliva if done properly. Get the Reddit app Scan this QR code to download the app now. Sublingual tablet 2 mg/0. I wish I understood the method better when I first started so I could give you my data, but I didn't so I can't compare the two ratios (the two E2:E1 ratios being one l via swallowing pills and two via sublingual buccal). This guide explores the science behind sublingual vs buccal absorption, the administration routes, their difference, and the advantages and disadvantages of these methods. oral. Does anyone know if buccal absorbtion has more absorption than sublingual? Is it the same? I looked it up couldn't get a for sure answer. I had read a post on Reddit by a doctor advocating for buccal administration of estradiol (over sublingual or swallowing). Sometimes labour is started artificially (induction) because of concerns for the well‐being of either the baby or the mother. However, I am sure that your post made it very clear to anyone what you were talking about, regardless of their background. Why is there different effects/duration for oral and sublingual/buccal if you end up swallowing the powder/herb? Is the amount so small with extracts it just dissolves in mouth, maybe that’s why. , 2011; Teubl et al. G. I had not heard about the half-life being longer for buccal/sublingual vs. I haven't done insufflation yet, just sublingual, but it really makes me wonder what the point is of insufflation. I was reading that (trans)buccal/sublabial administration (ie. I've tried taking the pills buccaly several times and I believe I do a better job at not swallowing parts of the pill that way. Yes, it is stronger. The medication dissolves through the lining of your cheeks. They're sort of like a nicotine patch where it sticks to the inside of your cheek. The article you linked is saying that you only need 1. putting dose between gum and cheek/lip) might be a good workaround for the excessively salivating and it certainly seems to work better. IV, but I want to look into that. Sublingual should work almost just as well though, you don't have to hold the saliva in for an hour. it's definitely way easier than sublingual, you can still drink and talk with the pills in (just can't eat). Crypto I’m curious if anyone has any experience with these 3 different routes of administration of RSO. I can even drink with a straw and talk a tiny it with buccal while with sublingual no chance. I took 35mg sublingual a few hours ago, within 20 minutes I was getting a crazy rush, my skin was pulsing with warmth and my vision got weird, looked in the mirror and my pupils were fucking huge. Both sublingual and buccal drugs come in tablets, films, or Sublingual and buccal are pretty much the same, it just depends on which method you find more convenient and easier to keep the tablet in place. Feb 15, 2023 · Unlike traditional oral or sublingual medications, buccal medications are placed between your gums and the inside of your cheek. Nov 4, 2019 · In terms of disadvantages (De Boer et al. Sublingual has popularity because more estrogen gets to your bloodstream as to bypass in through the liver , implying that oral hrt is less effective than sublingual. Why is oral / sublingual so unpopular among users? I mean, I‘m sure oral is not great for gums and sublingual not great for the tongue, but in the same way, intranasal is not great for the nose. I have a feeling, people saw the increase in sublingual zydis and it got muddied by word of mount the normal selegiline. r/suboxone A chip A close button. Aug 31, 2012 · The observed T max of ~1 h following sublingual administration of asenapine is shown to be consistent with the reported range of T max values following sublingual administration of other compounds found in the literature. It'll just take a while to dissolve. My doctor is against buccal administration, I was looking for any data that might compare the too. My general consensus is that oral hrt is doing more than sublingual is. 5 mg 4 mg/1 mg 8 mg/2 mg 12 mg/3 mg I've changed up the administration of my subs from sublingual to buccal after seeing a few posts about how it's better absorbed buccally. 18K subscribers in the AskMtFHRT community. Buccal DHF makes much more sense than sublingual. Bunavail and Zubsolv are also only indicated for maintenance therapy following induction by Suboxone. We would like to show you a description here but the site won’t allow us. Yes, you can take it sublingual. But realistically those differences are minor compared to the whole issue with swallowing with sublingual that doesn't happen as much with buccal. That being said, it is quite difficult to find other studies on the bioavailability of sublingual buprenorphine, with the addition of these new, more effective formulations of buccal buprenorphine. That winds up a lot easier. Okay, what is buccal? It's using the space between your cheek and gum. 2mg buccal films have equivalent bioavailability to 8mg Suboxone films. 5 mg Target: 1 6 mg/ 4 mg Range: 4 mg/1 mg to 24 mg/6 mg Generic monoproduct Buprenorphine hydrochloride Sublingual tablet 2 mg 8 mg Target: 1 6 mg Range: 4 mg to 24 mg Suboxone Buprenorphine hydrochloride Naloxone hydrochloride Sublingual film 2 mg/0. I've always taken my benzos sublingual but a simple Google… You feel buccal more because it has a higher bioavailability than sublingual. Moving from 8mg oral would be roughly equivalent to 4mg sublingual. Table 1 illustrates the comparable doses available for these 3 products. 25 buccal rather than 10mg oral, as it achieves the same effect for brain MAO-B inhibition while having less metabolites because of the lower dosage needed. Oral/recital absorbs about. (https://pubmed. Mar 22, 2016 · Although the pharmacokinetics among these 3 products are similar to the sublingual formulations, bioequivalence is variable. Jul 18, 2024 · The main characteristic of buccal and sublingual routes of administration is the rapid onset of action (several minutes), which is due to the high blood flow and lymphatic flow of the oral cavity. Effects only last like 1hr. Transdermal patches (used orally)? Hey everyone! I know when transdermal patches are used orally (placed between gums and cheek) such as durogesic, you only get about 50% of the fentanyl. Sublingual (dissolved under tongue), same dose and split: Oestradiol at 537 pmol/L So far sublingual has a big advantage. I continued that until I had GRS and went from 2mg transbuccal to 4mg transbuccal (I went from 6mg a day to 2mg a day two weeks before surgery, which is standard for my surgeon). There's no way i can switch to patches or injection because of lack of availability in my area there's only EV tablets which i take Sublingually 2mg every 6 hours (8mg/day) I was wondering, is there much difference as far as sublingual vs buccal goes for taking E? What I mean is, how does one vs the other work as far as entering the blood stream and impacting E levels? Buccal seems so so so much more convenient, you can talk, drink, swallow etc and not worry where as sublingual doesn't allow anything whatsoever. , 1984; Allen et al. Not all are designed for it. With buccal it's next once been an issue. Doing this without GP support as my current GP only listens to ASHS and I don't want them dropping my dose. 23,24 Both the buccal and transdermal formulations bypass first-pass gastrointestinal and hepatic metabolism, which could make these good analgesic options, especially for patients Business, Economics, and Finance. Jun 7, 2017 · Buccal administration involves placing a drug between your gums and cheek, where it also dissolves and is absorbed into your blood. Hey guys. Posted by u/Raven_Skyland - 1 vote and 16 comments BTW, do you work in the medical or dental field by chance? I am wondering because I do and I don't know any "civilians" who know what buccal and sublingual mean, lol. also they take a little longer to absorb this way than with sublingual, for me usually about 20mins for a 2mg pill. That being said, there is some evidence to suggest that sublingual creates more available estrogen, but you need to be taking the right kind of estradiol to be able to do sublingual anyways. New comments cannot be posted and votes cannot be cast. Thus, preclinical studies have found that sublingual vaccines can be highly immunogenic and may protect against influenza virus [4] [5] and Helicobacter pylori, [6] but sublingual administration may also be used for vaccines against other infectious diseases. I’m curious as to whether anyone has… Aug 20, 2022 · The buccal film formulation of buprenorphine has a higher bioavailability than other formulations, making it the most effective delivery method besides intravenous. Anyone care to weigh in on the efficacy of Oral vs Sublingual vs (Trans)buccal vs Sublabial administration of NMN with regards to bioavailability? Sublingual route of administration, will be similar, although somewhat less concentrated than buccal - whereby buccal administration of selegiline results in 5-fold higher bioavailability, more reproducible blood concentration, and produces less amphetamine metabolites than the oral tablet form. nih. Do not place the medicine on areas of the mouth with sores or lesions. so it becomes a little more important to take pills more frequently if you are interested in keeping your levels steady, which, i think is a good thing. Wren Reading it over the buccal results in a much better delivery than sublingual. I think it really comes down to personal preference, I've heard that buccally is slightly higher BA though I dont know for sure. Oral is longer lasting, with the weaker Estrone, whereas sublingual/buccal provide an almost immediate spike with a quick dropoff. I can't verify this number but another commenter said 95% is absorbed I have pills on hand, and have already taken Mifepristone. Only difference being sublingual has an average 40-45% BA, vs the average 60-65% BA when taken buccally. I frequently find sublingual pregnenolone to do nothing, while buccal seems to be doing something(I swear it brightens my mood and makes me feel better). What I do know is for me buccally is better because there's not so much saliva building up vs. I noticed a very significant difference between buccal and sublingual, to the degree that I'd consider buccal 10x more effective. ) I found that quickly wetting the tablet with saliva and then jamming it into my cheek helped kick-start it dissolving. Get app Get the Reddit app Log In Log in to Reddit. whats different with ingesting it from the stomach is that you send it to your liver first, before sending it to your brain. Open menu Open navigation Go to Reddit Home. 10 mg buccal and 10 mg oral should have the same metabolites. A reminder for everyone that this subreddit is for physiology discussion. If you won't use any anti androgens, keep the dosages higher (at least 3mg x 3 is good if you ask me) and I do urge you to consider rectal micronized progesterone. Or check it out in the app stores Home; Popular; TOPICS Sublingual vs Buccal Needing Advice Even if you take the buccal absorption rate from this other source, the results are, at best, identical in bioavailability. I'm currently on the 24-hour wait. Just put the thing in your tongue and once it dissolves you're good. As I was sitting, I thought about the differences between the three (sublingual, buccal, and vaginal). Here's my bro-science reasoning for taking my subs buccally Bunavail claims that their 4. Maybe ask them to increase your dose if you're still feeling withdrawal symptoms. The most common is oral mucosally, meaning absorbed under the tongue (sublingual) or between the cheek and gum (buccal). 1-. Both sublingual and buccal drugs come in tablets, films, or Sublingual has the best absorption- about 30% , peaks faster, dissipates sooner. “The E2 concentration achieved with the oral route is sufficient to prime the endometrium, in spite of the rapid metabolism through the enterohepatic circulation, and if necessary, oestradiol valerate may be given sublingually to bypass it. Oct 18, 2021 · For most patients, the ideal way to take Suboxone will be Sublingually, or under the tongue. Sublingual vs Buccal I'd like to know if it is even possible to absorb kanna through the cheek, instead of under the tongue. How much you absorb varies person to person. We do not provide medical guidance or diagnosis. How efficient are pharmaceutical sublingual/buccal fent tablets vs. 1990 Jul;46(3):796-812. Most patients choose the former route of sublingual administration as it is easier to hold a tincture under the tongue. 2/dose I’d say let it sit there as long as you can stand it, swallow spit and rinse out mouth, it seems to have less effect but I still feel a buzz this ROA (hyperfixation, energy and alertness) not so much euphoric like intranasal ingestion. To use the buccal film: Be careful not to cut or damage the film when opening the package. 20%- peaks slower lasts a little longer. 4mg E a day sublingual 100mg spiro a day swallowed T-17 ng/dL E-67 pg/mL I’m being up to 6mg a day, 2mg 3 times a day sublingually. I also do buccal, and my blood tests always come back in normal female range, even only taking 4mg/day. But maybe I‘m mistaken. What do you find are the different benefits of each… I use buccal instead of sublingual to be honest. No they are not, and yes they can. Personally, I found that sublingual dissolved too quickly because of the amount of saliva in my mouth (10-15 mins), meaning a lot is probably being swallowed. They have a very different design from subs, though. Jul 16, 2023 · By administering drugs through the sublingual and buccal routes, we can achieve faster onset of action, improved bioavailability, and reduced side effects. In my general area there is no such thing as “sublingual “ considering the lack of research . I've been wanting to get a stockpile going just in case, but I can't save any extras ever. In addition, substances absorbed at this level reach the general circulation without loss due to a first-pass effect, as the buccal venous drainage I do buccal mostly because sublingual produces too much saliva in my mouth. uxgkc lqdgea dlcykzf knggf ipdd zubzarx xmmu siqxci qgm pyj